Comparison of the Onset Times and Durations of Actions of Different Local Anesthetic Mixture Solutions [CODLAM]
Status:
Completed
Trial end date:
2017-11-30
Target enrollment:
Participant gender:
Summary
Objective To investigate the onset times and duration of local anesthetic mixture solutions
used for axillary-supraclavicular brachial plexus blocks and to compare the quality of
anesthesia in patients with trauma of the upper limb.
Design Randomized-prospective, observational study. Setting Perioperative, Trauma Clinic,
University of Pecs, Hungary. Participants 85 consecutive, unpremedicated ASA physical status
I-III patients, between the ages of 19 and 83, scheduled for trauma surgery of the hand and
forearm.
Interventions Patients assigned to four groups for standardized ultrasound guided
axillary-supraclavicular block with lidocaine 1% and bupivacaine 0,5% 1:1 mixture (Group LB,
n = 17) or bupivacaine 0.33% (Group BS, n = 14) or lidocaine 0,66% (Group LS, n = 14) or
bupivacaine 0.5% and lidocaine 1% 2:1 mixture (Group BL, n = 40). Total target volume of 0.4
ml/kg was administered to both groups.
Measurements Data were collected on patient demographics, the onset times and the duration of
actions of local anesthetic mixtures were measured, the tourniquet discomfort, vital
parameters, pre and postoperative verbal numeric rating scale of pain intensity,
anxiolytic/analgesic consumption and the complications were recorded. The quality of
anesthesia was assessed by a sensory-motor-coping-pain scale (0-16).
Phase:
N/A
Details
Lead Sponsor:
University of Pecs
Collaborator:
Medical University of Pecs
Treatments:
Anesthetics Anesthetics, Local Bupivacaine Lidocaine Pharmaceutical Solutions